Genetic polymorphism ofCYP1A2but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis.
AIM Leflunomide, via its active metabolite teriflunomide, is used in rheumatoid arthritis (RA) treatment, yet approximately 20 to 40% of patients cease due to toxicity. The aim was to develop a time-to-event model describing leflunomide cessation due to toxicity within a clinical cohort and to investigate potential predictors of cessation such as total and free teriflunomide exposure and pharma...
متن کاملCD226 rs763361 (Gly307Ser) Polymorphism Is Associated with Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. Methods: This case-control study was carried out on 100 patients with RA and 104 healthy su...
متن کاملthe itgav-rs3911238 polymorphism is associated with disease activity in rheumatoid arthritis.
evidences indicate that angiogenesis is an important process in the development of destructive synovial tissue in rheumatoid arthritis (ra). recently, it has been shown that the polymorphism of the integrin-αv subunit encoded by the itgav gene plays a role in angiogenesis and is considered as ra susceptibility loci. this study investigated association of four single nucleotide polymorphisms ...
متن کاملSemiphysiologically Based Pharmacokinetic Model of Leflunomide Disposition in Rheumatoid Arthritis Patients
A semiphysiologically based pharmacokinetic (semi-PBPK) population model was used to evaluate the influence of enterohepatic recycling and protein binding, as well as the effect of genetic variability in CYP1A2, CYP2C19, and ABCG2, on the large interindividual variability of teriflunomide (active metabolite) concentrations following leflunomide administration in rheumatoid arthritis (RA) patien...
متن کاملcd226 rs763361 (gly307ser) polymorphism is associated with susceptibility to rheumatoid arthritis in zahedan, southeast iran
background: rheumatoid arthritis (ra) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. the aim of the present study was to investigate the impact of cd226 rs727088 and rs763361 polymorphisms and susceptibility to ra in a sample of the iranian population. methods: this case-control study was carried out on 100 patients with ra and 104 healthy su...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2015
ISSN: 0306-5251
DOI: 10.1111/bcp.12760